MR imaging of diffusion of (3)He gas in healthy and diseased lungs.
نویسندگان
چکیده
Hyperpolarized (3)He gas MRI was used to form maps of the effective diffusivity of gas in human lungs. Images of diffusion as well as spin density are presented from a study of 11 healthy volunteers and 5 patients with severe emphysema. The effective rate of diffusion, D(e), of the gas is reduced by the alveolar walls; tissue destruction in emphysema is hypothesized to result in larger D(e). Indeed, the mean value of D(e) in the emphysematous lungs is found here to be about 2.5 times that of healthy lungs, although still smaller than the unrestricted diffusivity of (3)He in free air. Histograms of D(e) values across coronal slices are presented. The results are discussed in terms of spatial variations, variations among individuals, healthy and diseased, and variations due to changes in lung volume. Magn Reson Med 44:174-179, 2000.
منابع مشابه
Comparison Between Three-Dimensional Diffusion-Weighted PSIF Technique and Routine Imaging Sequences in Evaluation of Peripheral Nerves in Healthy People
Introduction: The present study aims to evaluate the Three-Dimensional Diffusion-Weighted reversed fast imaging with steady state free precession (3D DW-PSIF) sequence with respect to imaging of the peripheral nerves; the tibial, medial, and lateral plantar nerves in the lower extremity, ulnar and median nerve in the upper extremity, sciatic nerve, brachial plexus, and lumbosacral plexus, and a...
متن کاملApplications of diffusion weighted imaging in detection of radiating pain to lower extremities
Introduction: To examine the hypothesis that diffusion weighted imaging (DWI) in lumbosacral region could reveal sciatic nerve course swelling that lead to lower extremity pain. The aim of present article was to find and evaluate the diffusion weighted coefficients (b-values) for scrutinizing sciatic nerve tract changes in lumbosacral region. Materials and methods: Lumbar area was imaged in 30...
متن کاملDifferentiation of active tumor from edematous regions of glioblastoma multiform tumor in diffusion MR images using heterogeneity analysis method
Background: Due to intrinsic heterogeneity of cellular distribution and density within diffusion weighted images (DWI) of glioblastoma multiform (GBM) tumors, differentiation of active tumor and peri-tumoral edema regions within these tumors is challenging. The aim of this paper was to take advantage of the differences among heterogeneity of active tumor and edematous regions within the gliobla...
متن کاملDynamic Contrast Magnetic Resonance Imaging (DCE-MRI) and Diffusion Weighted MR Imaging (DWI) for Differentiation between Benign and Malignant Salivary Gland Tumors
Background: Salivary gland tumors form nearly 3% of head and neck tumors. Due to their large histological variety and vicinity to facial nerves, pre-operative diagnosis and differentiation of benign and malignant parotid tumors are a major challenge for radiologists. Objective: The majority of these tumors are benign; however, sometimes they tend to transform into a malignant form. Functional M...
متن کاملRF instrumentation for same‐breath triple nuclear lung MR imaging of 1H and hyperpolarized 3He and 129Xe at 1.5T
PURPOSE The hyperpolarized gases (3)He and (129)Xe have distinct properties and provide unique and complementary functional information from the lungs. A triple-nuclear, same-breath imaging examination of the lungs with (1)H, (3)He, and (129)Xe can therefore provide exclusive functional information from the gas images. In addition, the (1)H images provide complementary co-registered structural ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Magnetic resonance in medicine
دوره 44 2 شماره
صفحات -
تاریخ انتشار 2000